SAFit1 | FKBP51 inhibitor | Probechem Biochemicals

Chemical Structure : SAFit1

CAS No.: 1643125-32-9

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SAFit1 (FKBP51 inhibitor SAFit1)

货号: PC-72576Not For Human Use, Lab Use Only.

SAFit1 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 4 nM, >10,000-fold selectivity over FKBP52.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4980	In stock
50 mg		Get quote

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生物&药学活性

SAFit1 is a potent and highly selective inhibitor of FKBP51 (K506-binding protein 51) with IC50 of 4 nM, >10,000-fold selectivity over FKBP52.
SAFit1 dose-dependently stimulates neurite outgrowth in primary hippocampal neurons derived from E18 mouse embryos.
SAFit1 showed antidepressant-like effects and partly prevented the inhibitory effects of dexamethasone on glucose uptake.

物理化学性质&存储条件

分子量	747.88
分子式	C42H53NO11
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(3-((R)-1-((S)-1-((S)-2-cyclohexyl-2-(3,4,5-trimethoxyphenyl)acetyl)piperidine-2-carbonyloxy)-3-(3,4-dimethoxyphenyl)propyl)phenoxy)acetic acid

参考文献

1. Gaali S, et al. Nat Chem Biol. 2015 Jan;11(1):33-7.

2. Sidibeh CO, et al. Endocrine. 2018 Oct;62(1):116-128.

SAFit1 (FKBP51 inhibitor SAFit1)

生物&药学活性

物理化学性质&存储条件

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SAFit1 (FKBP51 inhibitor SAFit1)

生物&药学活性

物理化学性质&存储条件

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