SACLAC

Chemical Structure : SACLAC

CAS No.: 2248703-42-4

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货号: PC-72408Not For Human Use, Lab Use Only.

SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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生物&药学活性

SACLAC is an α-chloroamide ceramide analog that binds irreversibly to acid ceramidase (ASAH1), significantly reduces the viability of AML cells (EC50=3 uM) across 30 human AML cell lines.
SACLAC induces apoptosis and loss of mitochondrial membrane potential, reduces cell viability and colony formation, reduces expression of SF3B1 and increases pro-apoptotic Mcl-1S.
SACLAC (5 mg/kg SACLAC in 45% w/v 2-hydroxypropyl-β-cyclodextrin in PBS) reduces leukemic burden in NSG mouse models of AML.

物理化学性质&存储条件

分子量	377.994
分子式	C20H40ClNO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-chloro-N-((2S,3R)-1,3-dihydroxyoctadecan-2-yl)acetamide

参考文献

1. Jennifer M Pearson, et al. Mol Cancer Res. 2020 Mar;18(3):352-363.

SACLAC

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物理化学性质&存储条件

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SACLAC

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