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首页-小分子抑制剂&激动剂-Others-Other Targets-SABRAC
SABRAC

Chemical Structure : SABRAC

CAS No.: 886212-98-2

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SABRAC

货号: PC-22606Not For Human Use, Lab Use Only.

SABRAC is a highly potent, irreversible inhibitor of acid ceramidase with Ki of 29.7 nM, induces apoptosis and provides a benefit in mice survival in IDH1 mut oligodendroglioma.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SABRAC is a highly potent, irreversible inhibitor of acid ceramidase with Ki of 29.7 nM, induces apoptosis and provides a benefit in mice survival in IDH1 mut oligodendroglioma.

物理化学性质&存储条件

分子量 422.45
分子式 C20H40BrNO3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-Bromo-N-[(1S,2R)-2-hydroxy-1-(hydroxymethyl)heptadecyl]acetamide

参考文献

1. Ordóñez YF, et al. J Am Chem Soc. 2019 May 15;141(19):7736-7742.

2. Muley H, et al. bioRxiv [Preprint]. 2024 Apr 29:2024.04.27.591426.

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