SA00025 | NURR1 agonist | Probechem Biochemicals

Chemical Structure : SA00025

CAS No.: 1015231-98-7

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SA00025 (SA 00025, SA-00025)

货号: PC-20772Not For Human Use, Lab Use Only.

SA00025 is a potent, specific and brain penetrant agonist of Nurr1 (NR4A2) with EC50 of 2.5 nM in HEK293 cells transfected with full length human Nurr1.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
100 mg		Get quote
1 g		Get quote

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生物&药学活性

SA00025 is a potent, specific and brain penetrant agonist of Nurr1 (NR4A2) with EC50 of 2.5 nM in HEK293 cells transfected with full length human Nurr1.
SA00025 does not activate panel of 40 other nuclear receptors, including RXR.
SA00025 (30mg/kg for 7 days, oral gavage) modulated the transcription of dopaminergic target genes in brain of naive rats, induced a transcriptional upregulation of Nurr1, TH and VMAT.
SA00025 caused neuroprotection in the 6-OHDA lesion model primed with the TLR3 dsRNA inflammatory stimulant (poly(I:C)).
SA00025 displayed anti-inflammatory activity in the 6-OHDA lesion model primed with the TLR3 dsRNA inflammatory stimulant (poly(I:C)).

物理化学性质&存储条件

分子量	362.86
分子式	C22H19ClN2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-{3-[2-(4-chlorophenyl)imidazo[1,2-a]-pyridin-6-yl]phenyl}propan-2-ol

参考文献

1. Gaynor A Smith, et al. PLoS One. 2015 Mar 27;10(3):e0121072.

2. Patent WO2008034974A1.

3. Lesuisse D, et al. Bioorg Med Chem Lett. 2019 Apr 1;29(7):929-932.

SA00025 (SA 00025, SA-00025)

生物&药学活性

物理化学性质&存储条件

参考文献

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SA00025 (SA 00025, SA-00025)

生物&药学活性

物理化学性质&存储条件

参考文献

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