S9-A13 | SLC26A9 inhibitor | Probechem Biochemicals

Chemical Structure : S9-A13

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S9-A13 (S 9-A13)

货号: PC-49386Not For Human Use, Lab Use Only.

S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively.

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生物&药学活性

S9-A13 is a highly potent and specific inhibitor of SLC26A9, potently inhibits SLC26A9-mediated Cl−/I− and Cl−/SCN− exchange activities with IC50 of 90.9 and 171.5 nM, respectively.
S9-A13 does not inhibit other members of the SLC26 family and has no effects on Cl− channels such as CFTR, TMEM16A, or VRAC.
S9-A13 (0-1 uM ) inhibits SLC26A9 currents in a dose-dependent manner in HEK293 cells, but shows little effects on CFTR currents in HEK293 cells at the highest concentration (5 uM).
S9-A13 has a minor effect on ion transport in human airway epithelial cells and mouse trachea, despite clear expression of SLC26A9 in the apical membrane of ciliated cells.

物理化学性质&存储条件

分子量	399.893
分子式	C20H18ClN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-chloro-4-methylphenyl)-3-methyl-4-(5-methylthiophene-2-carbonyl)-1,4,5,7-tetrahydro-6H-pyrazolo[3,4-b]pyridin-6-one

参考文献

1. Sungwoo Jo, et al. FASEB J. 2022 Nov;36(11):e22534.

S9-A13 (S 9-A13)

生物&药学活性

物理化学性质&存储条件

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S9-A13 (S 9-A13)

生物&药学活性

物理化学性质&存储条件

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