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首页-小分子抑制剂&激动剂-GPCR-Taste Receptor-S6821
S6821

Chemical Structure : S6821

CAS No.: 1119831-25-2

S6821 (S 6821, S-6821)

货号: PC-72152Not For Human Use, Lab Use Only.

S6821 (S 6821) is a potent and selective bitter taste receptor TAS2R8 with IC50 of 21 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    S6821 (S 6821) is a potent and selective bitter taste receptor TAS2R8 antagonist with IC50 of 21 nM.
    S6821 shows high selectivity against a panel of 16 TAS2Rs, effectively attenuates the bitterness of coffee, and displays very good safety profiles.

    物理化学性质&存储条件

    分子量 381.392
    分子式 C19H19N5O4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    3-(1-((3,5-dimethylisoxazol-4-yl)methyl)-1H-pyrazol-4-yl)-1-(3-hydroxybenzyl)imidazolidine-2,4-dione

    参考文献

    1. Fotsing JR, et al. J Med Chem. 2020 May 14;63(9):4957-4977.

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