S64315 |CAS:1799631-75-6 Probechem Biochemicals

Chemical Structure : S64315

CAS No.: 1799631-75-6

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S64315 (MIK665, S-64315, MIK-665)

货号: PC-35691Not For Human Use, Lab Use Only.

MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.

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5 mg	￥2880	In stock
10 mg	￥4780	In stock
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生物&药学活性

MIK665 (S-64315, MIK-665) is a novel potent, selective Mcl-1 inhibitor (IC50=1.8 nM) with potential pro-apoptotic and antineoplastic activities.
MIK665 (S-64315) binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1.
Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.

物理化学性质&存储条件

分子量	875.413
分子式	C47H44ClFN6O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((2-(2-methoxyphenyl)pyrimidin-4-yl)methoxy)phenyl)propanoic acid

参考文献

1. Cassier PA, et al. Br J Cancer. 2017 Oct 10;117(8):1089-1098.

S64315 (MIK665, S-64315, MIK-665)

生物&药学活性

物理化学性质&存储条件

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S64315 (MIK665, S-64315, MIK-665)

生物&药学活性

物理化学性质&存储条件

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