S62798 | TAFIa inhibitor | Probechem Biochemicals

Chemical Structure : S62798

加入收藏

S62798 (S 62798, S-62798)

货号: PC-72788Not For Human Use, Lab Use Only.

S62798 (S 62798) is a highly selective human, mouse and rat TAFIa (Thrombin Activatable Fibrinolysis Inhibitor) inhibitor with IC50 of 11, 270, 178 nM respectively.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

S62798 (S 62798) is a highly selective human, mouse and rat TAFIa (Thrombin Activatable Fibrinolysis Inhibitor) inhibitor with IC50 of 11, 270, 178 nM respectively.
S62798 accelerates lysis of a human clot in vitro, evaluated by thromboelastometry (EC50=27 nM).
In a rat tail bleeding model, no effect of S62798 treatment was observed up to 20 mg/kg.
Enhancement of endogenous fibrinolysis by S62798 was investigated in a mouse model of Tissue Factor-induced pulmonary thromboembolism.
Intravenous administration of S62798 decreased pulmonary fibrin clots with a minimal effective dose of 0.03 mg/kg.

物理化学性质&存储条件

分子量	438.4402
分子式	C20H28FN4O4P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1,4-Azaphosphorine-3-carboxylic acid, 3-(4-aminobutyl)-1-[[4-fluoro-2-(1-methyl-1H-imidazol-5-yl)phenyl]methyl]hexahydro-4-hydroxy-, 4-oxide, (3S)-

参考文献

1. Sansilvestri-Morel P, et al. Thromb Res. 2021 Aug;204:81-87.

S62798 (S 62798, S-62798)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

S62798 (S 62798, S-62798)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.