S3I-M2001 |CAS:1003580-86-6 Probechem Biochemicals

Chemical Structure : S3I-M2001

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S3I-M2001 (S3I M2001;Bromohydroxyacetone phosphate)

货号: PC-62347Not For Human Use, Lab Use Only.

S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers.

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生物&药学活性

S3I-M2001 (Bromohydroxyacetone phosphate) is an oxazole-based peptidomimetic of the STAT3 SH2 domain-binding phosphotyrosine peptide that selectively disrupts active STAT3:STAT3 dimers.
S3I-M2001 inhibits Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL.
S3I-M2001 suppresses Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently activated Stat3。
S3I-M2001 inhibits growth of human breast tumor xenografts.

物理化学性质&存储条件

分子量	508.511
分子式	C27H29N2O6P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-{[4-(Hexylcarbamoyl)-2-(1-naphthyl)-1,3-oxazol-5-yl]methyl}phen yl dihydrogen phosphate

参考文献

1. Siddiquee KA, et al. ACS Chem Biol. 2007 Dec 21;2(12):787-98.

S3I-M2001 (S3I M2001;Bromohydroxyacetone phosphate)

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物理化学性质&存储条件

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S3I-M2001 (S3I M2001;Bromohydroxyacetone phosphate)

生物&药学活性

物理化学性质&存储条件

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