S3I-1757

Chemical Structure : S3I-1757

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货号: PC-20628Not For Human Use, Lab Use Only.

S3I-1757 is a small molecule STAT3-STAT3 dimerization inhibitor with IC50 of 13.5 uM in fluorescence polarization (FP) assays, interacts with Y-705 binding site in the SH2 domain.

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50 mg		Get quote
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1 g		Get quote

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生物&药学活性

S3I-1757 is a small molecule STAT3-STAT3 dimerization inhibitor with IC50 of 13.5 uM in fluorescence polarization (FP) assays, interacts with Y-705 binding site in the SH2 domain.
S3I-1757 disrupts intracellular STAT3-STAT3 dimerization and STAT3-EGFR binding in intact cells.
S3I-1757 (50-200 uM) decreases phosphotyrosine STAT3 levels in the nucleus of human MDA-MB-468 breast cancer cells, inhibits STAT3-DNA binding.
S3I-1757 (50-200 uM, 18h) inhibits STAT3-dependent transcriptional activity and decreases the expression of STAT3-regulated genes in MDA-MB-468 cells.
S3I-1757 inhibits anchorage-dependent proliferation selectively, and inhibits migration and invasion selectively in human cancers that harbor high levels of P-STAT3.

物理化学性质&存储条件

分子量	521.61
分子式	C33H31NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5-[[(4-Cyclohexylphenyl)methyl](4-phenoxybenzoyl)amino]-2-hydroxybenzoic acid

参考文献

1. Zhang X, et al. Cancer Res. 2013 Mar 15;73(6):1922-33.

S3I-1757

生物&药学活性

物理化学性质&存储条件

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S3I-1757

生物&药学活性

物理化学性质&存储条件

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