S3969 | ENaC activator | Probechem Biochemicals

Chemical Structure : S3969

CAS No.: 1027997-01-8

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S3969 (S 3969)

货号: PC-21839Not For Human Use, Lab Use Only.

S3969 is a small molecule activator of the human epithelial sodium channel (ENaC) with EC50 of 1.2 uM in ENaC-expressing oocytes.

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5 mg	￥4580	In stock
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生物&药学活性

S3969 is a small molecule activator of the human epithelial sodium channel (ENaC) with EC50 of 1.2 uM in ENaC-expressing oocytes.
S3969 can fully and reversibly activates human ENaC (hENaC) in an amiloride-sensitive and dose-dependent manner in heterologous cells.
S3969 activates hENaC following removal of amiloride, increases hENaC open probability.
S3969 activates δβγ hENaC but not αβγ mENaC, opens ENaC channels not cleaved by furin proteolysis.
S3969 increases hENaC open probability through interactions requiring the extracellular domain of the β subunit.

物理化学性质&存储条件

分子量	320.45
分子式	C17H24N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(2-hydroxyethyl)-4-methyl-2-(4-methyl-1H-indol-3-ylthio)pentanamide

参考文献

1. Lu M, et al. J Biol Chem. 2008 May 2;283(18):11981-94.

2. Huber R, et al. Cell Physiol Biochem. 2010;25(1):145-58.

3. Sure F, et al. J Biol Chem. 2024 Feb 22:105785.

S3969 (S 3969)

生物&药学活性

物理化学性质&存储条件

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S3969 (S 3969)

生物&药学活性

物理化学性质&存储条件

参考文献

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