S2C3 | HIV entry inhibitor | Probechem Biochemicals

Chemical Structure : S2C3

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S2C3 (HIV-1 fusion inhibitor S2C3)

货号: PC-73247Not For Human Use, Lab Use Only.

S2C3 is a small molecule HIV-1 fusion inhibitor, targets the membrane proximal external region (MPER) of HIV-1 envelope spike.

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生物&药学活性

S2C3 is a small molecule HIV-1 fusion inhibitor, targets the membrane proximal external region (MPER) of HIV-1 envelope spike.
S2C3 interacted with gp41-inter with an affinity of 2.0 uM.
S2C3 has been shown to effectively block binding to the intact HIV-1 Env expressed on the cell surface by soluble CD4 but not by CD4 binding the sitedirected NAb VRC01, or the prefusion conformation-specific NAb PG16.
S2C3 targets a site in the HIV-1 Env distinct from sites targeted by small-molecule entry inhibitors that have been identified so far.
S2C3 could stabilize HIV-1 Env in the prefusion conformation, making it potentially useful in a vaccine preparation to reduce the conformational flexibility of Env.

物理化学性质&存储条件

分子量	724.67
分子式	C38H52Br2N4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4,4'-(tetradecane-1,14-diyl)bis(9-amino-2,3-dihydro-1H-cyclopenta[b]quinolin-4-ium) bromide

参考文献

1. Tianshu Xiao, et al. Nat Chem Biol. 2020 May; 16(5): 529–537.

S2C3 (HIV-1 fusion inhibitor S2C3)

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物理化学性质&存储条件

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S2C3 (HIV-1 fusion inhibitor S2C3)

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物理化学性质&存储条件

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