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首页-小分子抑制剂&激动剂-Others-Other Targets-S29434
S29434

Chemical Structure : S29434

CAS No.: 874484-20-5

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S29434 (S 29434;S-29434)

货号: PC-35919Not For Human Use, Lab Use Only.

S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.

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5 mg ￥1880 In stock
10 mg ￥2980 In stock
25 mg ￥4880 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

S29434 (S 29434) is a highly potent, selective, cell-active inhibitor of Quinone reductase 2 (QR2) with IC50 of 5-16 nM, shows good selectivity for QR2 over QR1.
S29434 inhibits QR2-mediated ROS production within the 100 nM range in various cell types, including hepatoma HepG2 cells, the astroglial cell line U373 and primary dopaminergic neurons.
S29434 (S 29434) is fairly stable in vivo.

物理化学性质&存储条件

分子量 374.4
分子式 C21H18N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-(2-methoxy-6H-dipyrido[2,3-a:3',2'-e]pyrrolizin-11-yl)ethyl)furan-2-carboxamide

参考文献

1. Boutin JA, et al. Mol Pharmacol. 2018 Dec 19. pii: mol.118.114231. doi: 10.1124/mol.118.114231.

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