S2172

Chemical Structure : S2172

加入收藏

货号: PC-23355Not For Human Use, Lab Use Only.

S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

S2172 is a specific, brain penetrant inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with Ki of 0.27 uM.
S2172 does not inhibit LSD2, monoamine oxidase A (MAO-A), and MAO-B, in an in vitro peroxidase assay.
S2172 inhibits cell growth effectively (GI50=8.2 μM) against differentiated glioma cell lines (LN229).
S2172 affects H3K4me2 modifications, affects super-enhancer-dependent regulation of gene expression in GSCs.
S2172 (10 mg/kg) eradicates tumor cells in GSC brain tumor mouse model.

物理化学性质&存储条件

分子量	372.46
分子式	C22H26F2N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-N1-[(1R,2S)-2-[3,5-Difluoro-2-(phenylmethoxy)phenyl]cyclopropyl]-1,4-cyclohexanediamine

参考文献

1. Shinjo K, et al. Cancer Gene Ther. 2024 Nov 5. doi: 10.1038/s41417-024-00847-8.

S2172

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

S2172

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.