S2157

Chemical Structure : S2157

加入收藏

货号: PC-23356Not For Human Use, Lab Use Only.

S2157 is a selective, brain-permeable inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with IC50 of 0.89 uM, >200-fold selective over LSD2, MAO-A and MAO-B.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

S2157 is a selective, brain-permeable inhibitor of lysine-specific demethylase 1 (LSD1, KDM1A) with IC50 of 0.89 uM, >200-fold selective over LSD2, MAO-A and MAO-B.
S2157 prevented teratoma formation from hiPSCs transplanted into immunodeficient mice.
S2157 induced apoptosis in TCP-resistant T-ALL cells in vitro and in vivo by repressing transcription of the NOTCH3 and TAL1 genes through increased H3K9 methylation and reciprocal H3K27 deacetylation at superenhancer regions.
S2157 significantly retarded the growth of T-ALL cells in xenotransplanted mice and prolonged the survival of recipients as monotherapy and in combination with dexamethasone.
S2157 could almost completely eradicate CNS leukemia.

物理化学性质&存储条件

分子量	415.48
分子式	C23H27F2N3O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	rel-2-[[(1R,2S)-2-[3,5-Difluoro-2-(phenylmethoxy)phenyl]cyclopropyl]amino]-1-(4-methyl-1-piperazinyl)ethanone

参考文献

1. Saito S, et al. Clin Cancer Res. 2019 Mar 1;25(5):1601-1611.

2. Osada N, et al. Oncotarget. 2018 Jan 8;9(5):6450-6462.

S2157

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

S2157

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.