S21-1011

Chemical Structure : S21-1011

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货号: PC-22297Not For Human Use, Lab Use Only.

S21-1011 is a potent, selective, BBB-penetrant butyrylcholinesterase (BChE) inhibitor with IC50 of 59 nM and 162 nM for eqBChE and hBChE, respectively.

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生物&药学活性

S21-1011 is a potent, selective, BBB-penetrant butyrylcholinesterase (BChE) inhibitor with IC50 of 59 nM and 162 nM for eqBChE and hBChE, respectively.
S21-1011 displays 508-fold and 190-fold selectivity for eqBChE and hBChE over electrophorus electricus AChE (eeAChE), respectively.
S21-1011 shows europrotective effects against H2O2-induced neuronal damages on PC12 cells.
S21-1011 plays a neuroprotective and anti-oxidative character to protect cells from damages triggered by Aβ, LPS and H2O2.
S21-1011 functions as a neuroprotective role via activating Nrf2 pathway and resisting inflammation injuries.
S21-1011 alleviates cognitive impairment caused by Aβ deposits in various AD model mice.

物理化学性质&存储条件

分子量	464.61
分子式	C30H32N4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(4-benzylpiperazin-1-yl)quinolin-3-yl)-4-propylbenzamide

参考文献

1. Ying Chen, et al. Eur J Med Chem. 2024 Apr 30:272:116463.

S21-1011

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物理化学性质&存储条件

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S21-1011

生物&药学活性

物理化学性质&存储条件

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