S1g-2 | Hsp70-Bim inhibitor | Probechem Biochemicals

Chemical Structure : S1g-2

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S1g-2 (Hsp70-Bim inhibitor S1g-2)

货号: PC-38154Not For Human Use, Lab Use Only.

S1g-2 (Hsp70-Bim inhibitor S1g-2) is a selective inhibitor to block interactions of Hsp70-Bim with IC50 of 0.4 uM in FPA assays, > 40-fold selectivity to target Hsp70-Bim over Bcl-2-Bim.

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生物&药学活性

S1g-2 (Hsp70-Bim inhibitor S1g-2) is a selective inhibitor to block interactions of Hsp70-Bim with IC50 of 0.4 uM in FPA assays, > 40-fold selectivity to target Hsp70-Bim over Bcl-2-Bim.
S1g-2 induces cell-type-specific apoptosis in CML cells through selectively disrupting the Hsp70-Bim PPI.
S1g-2 progressively enhanced lethality along with the increase in BCR-ABL-independent TKI resistance in the K562 cell lines.
S1g-2 is more effective in primary samples from BCR-ABL-independent TKI-resistant patients than those from TKI-sensitive patients.

物理化学性质&存储条件

分子量	420.527
分子式	C24H24N2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	methyl 3-((2-cyano-6-(cyclohexylthio)-1-oxo-1H-phenalen-3-yl)amino)propanoate

参考文献

1. Ting Song, et al. Leukemia. 2021 Oct;35(10):2862-2874.

S1g-2 (Hsp70-Bim inhibitor S1g-2)

生物&药学活性

物理化学性质&存储条件

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S1g-2 (Hsp70-Bim inhibitor S1g-2)

生物&药学活性

物理化学性质&存储条件

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