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首页-小分子抑制剂&激动剂-Proteasome/Ubiquitin-Heat Shock Protein (HSP)-S1g-10
S1g-10

Chemical Structure : S1g-10

CAS No.: 3032432-71-3

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S1g-10 (Hsp70-Bim PPI inhibitor)

货号: PC-22673Not For Human Use, Lab Use Only.

S1g-10 is a potent Hsp70-Bim protein-protein interaction (PPI) inhibitor with Kd of 688 nM, inhibits CML cells in the sub-μM range, overcomes BCR-ABL-independent tyrosine kinase inhibitor resistance in CML in vivo.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

S1g-10 is a potent Hsp70-Bim protein-protein interaction (PPI) inhibitor with Kd of 688 nM, inhibits CML cells in the sub-μM range, overcomes BCR-ABL-independent tyrosine kinase inhibitor resistance in CML in vivo.

物理化学性质&存储条件

分子量 433.61
分子式 C26H31N3OS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1H-Phenalene-2-carbonitrile, 6-(cyclohexylthio)-3-[[2-(diethylamino)ethyl]amino]-1-oxo-

参考文献

1. Wang Z, et al. J Med Chem. 2023 Dec 14;66(23):16377-16387.

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