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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-ROR-S18-000003
S18-000003

Chemical Structure : S18-000003

CAS No.: 2068119-11-7

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S18-000003 (S 18-000003)

货号: PC-35828Not For Human Use, Lab Use Only.

S18-000003 (S18-000003) is a potent, selective, orally bioavailable RORγt inhibitor with IC50 of 29 nM (hRORγt, GAL4), shows no significant activity against RORα, RORβ and LXRα/β(IC50>10 uM).

规格 价格 库存 数量
5 mg ￥1280 In stock
10 mg ￥1980 In stock
25 mg ￥3580 In stock
50 mg ￥5480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

S18-000003 (S18-000003) is a potent, selective, orally bioavailable RORγt inhibitor with IC50 of 29 nM (hRORγt, GAL4), shows no significant activity against RORα, RORβ and LXRα/β(IC50>10 uM).
S18-000003 inhibits IL-17 production in the skin of IL-23-treated mice by oral administration (30 mg/kg).

物理化学性质&存储条件

分子量 518.551
分子式 C26H25F3N2O4S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2,4-difluorophenyl)-2-(4-(2-(4-(ethylsulfonyl)phenyl)acetamido)-2-fluorophenyl)-2-methylpropanamide

参考文献

1. Sasaki Y, et al. Bioorg Med Chem Lett. 2018 Dec 1;28(22):3549-3553.

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