S107 | RyR2 stabilizer | Probechem Biochemicals

Chemical Structure : S107

CAS No.: 927871-76-9

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S107 (RyR2 stabilizer S107)

货号: PC-21371Not For Human Use, Lab Use Only.

S107 (RyR2 stabilizer) is a specific stabilizing cmpound of Ca2+ release channel ryanodine receptor 2 (RyR2), enhances calstabin2 binding and inhibits Ca2+ leak from mutant RyR2 channels.

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10 mg	￥1880	In stock
25 mg	￥2980	In stock
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生物&药学活性

S107 (RyR2 stabilizer) is a specific stabilizing cmpound of Ca2+ release channel ryanodine receptor 2 (RyR2), enhances calstabin2 binding and inhibits Ca2+ leak from mutant RyR2 channels.
S107 does not interact with over 400 receptors, enzymes, and ion channels in screens using up to 10 μM.
S107 also shows no effect on cardiac ion channels including the voltage-gated Na+, K+, and Ca2+ channels at concentrations up to 10 μM, and no effect on normal Ca2+ signaling in cells.
S107 prevents depletion of calstabin1 from the RyR1 complex improved force generation and exercise capacity, reduced Ca2+-dependent neutral protease calpain activity and plasma creatine kinase levels.
S107 improves Ca2+ handling in muscle fibers and reduces muscle fatigue.

物理化学性质&存储条件

分子量	209.31
分子式	C11H15NOS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine

参考文献

1. Lehnart SE, et al. J Clin Invest. 2008 Jun;118(6):2230-45.

2. Bellinger A.M., et al. Proc. Natl. Acad. Sci. U. S. A. 2008;105:2198–2202.

3. Wehrens XH, et al. Science. 2004;304:292–296.

S107 (RyR2 stabilizer S107)

生物&药学活性

物理化学性质&存储条件

参考文献

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S107 (RyR2 stabilizer S107)

生物&药学活性

物理化学性质&存储条件

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