S07-2010

Chemical Structure : S07-2010

CAS No.:

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货号: PC-24205Not For Human Use, Lab Use Only.

S07-2010 is a potent, pan aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 0.19, 0.36, 0.47, and 0.73 uM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively.

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5 mg	￥880	In stock
10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

S07-2010 is a potent, pan aldo-keto reductase 1C3 (AKR1C3) inhibitor with IC50 of 0.19, 0.36, 0.47, and 0.73 uM for AKR1C3, AKR1C4, AKR1C1 and AKR1C2, respectively.
S07-2010 exhibits obvious cytotoxicity on MCF-7/DOX and A549/DDP, with IC50 = 127.5 and 5.51 μM, respectively.
S07-2010 reverses the resistance of the cancer cells to DDP and inhibited tumor proliferation at low concentrations in A549/DDP cells.
S07-2010 combined with chemotherapeutic agents promotes apoptosis of cancer cells.

物理化学性质&存储条件

分子量	371.46
分子式	C19H21N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	7-(2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetyl)-1,3,4,5-tetrahydro-2H-benzo[b]azepin-2-one

参考文献

1. He S, et al. ACS Med Chem Lett. 2022 Jul 8;13(8):1286-1294.

S07-2010

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S07-2010

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