S. aureus antibiotic 1

Chemical Structure : S. aureus antibiotic 1

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货号: PC-21954Not For Human Use, Lab Use Only.

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1 g		Get quote

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生物&药学活性

S. aureus antibiotic 1 is a novel antibiotic exhibiting antibiotic activity against Staphylococcus aureus (MIC=4 ug/mL, MRSA USA300), can overcome common resistance determinants and antibiotic tolerance in Gram-positive bacteria.
S. aureus antibiotic 1 displays no cytotoxicity against HepG2 cells, HSkMCs, and IMR-90 cells.
S. aureus antibiotic 1 exhibits a structural scaffold distinct from those of known antibiotics.
S. aureus antibiotic 1 exhibits MIC ranges 2 to 16 ug/mL for 40 US Centers for Disease Control and Prevention (CDC) isolates of different bacterial species containing various resistance factors, including vancomycin, aminoglycoside/tetracycline and oxazolidinone resistance.
S. aureus antibiotic 1 is selective against methicillin-resistant S. aureus (MRSA) and vancomycin-resistant enterococci, evades substantial resistance, and reduces bacterial titres in mouse models of MRSA skin and systemic thigh infection.

物理化学性质&存储条件

分子量	374.60
分子式	C15H10Cl3NO4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-chloro-2-(2-(2,4-dichlorophenoxy)acetamido)benzoic acid

参考文献

1. Felix Wong, et al. Nature. 2024 Feb;626(7997):177-185.