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首页-小分子抑制剂&激动剂-Others-Other Targets-S-Y048
S-Y048

Chemical Structure : S-Y048

CAS No.: 2020058-38-0

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S-Y048 ((S)-Y048)

货号: PC-72738Not For Human Use, Lab Use Only.

S-Y048 ((S)-Y048) is a highly potent, selective OXE receptor antagonist, inhibits 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils with pIC50 of 10.8 (20 pM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    S-Y048 ((S)-Y048) is a highly potent, selective OXE receptor antagonist, inhibits 5‐oxo‐ETE‐induced calcium mobilization in human neutrophils with pIC50 of 10.8 (20 pM).
    S‐Y048 (10 nM) completely blocked actin polymerization induced in human eosinophils by 5‐oxo‐ETE.
    S‐Y048 had no effect on actin polymerization in eosinophils in response to identical concentrations of PGD2, LTB4, or human eotaxin‐1, S‐Y048 (1 uM) blocked 5‐oxo‐ETE‐induced actin polymerization in neutrophils but had no effect on the response to LTB4.
    S-Y048 inhibited allergen-induced eosinophil infiltration into the skin of rhesus monkeys that had been experimentally sensitized to house dust mite and inhibited pulmonary inflammation resulting from challenge with aerosolized allergen.

    物理化学性质&存储条件

    分子量 488.449
    分子式 C27H31Cl2NO3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-5-(5-chloro-2-(6-(3-chlorophenyl)hexyl)-1-methyl-1H-indol-3-yl)-3-methyl-5-oxopentanoic acid

    参考文献

    1. Miller LA, et al. Br J Pharmacol. 2020 Jan;177(2):360-371.

    2. Ye Q, et al. Br J Pharmacol. 2020 Jan;177(2):388-401.

    3. Powell WS, et al. Biochem Pharmacol. 2020 Sep;179:113930.

    4. Cossette C, et al. Br J Pharmacol. 2022 Jan;179(2):322-336.

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