S-777469 | CB2 agonist | Probechem Biochemicals

Chemical Structure : S-777469

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S-777469 (S777469)

货号: PC-49218Not For Human Use, Lab Use Only.

S-777469 (S777469) is a potent, selective, orally available cannabinoid receptor 2 (CB2) receptor agonist with Ki value of 32 nM (hCB2), >100-fold selectivity over CB1.

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生物&药学活性

S-777469 (S777469) is a potent, selective, orally available cannabinoid receptor 2 (CB2) receptor agonist with Ki value of 32 nM (hCB2), >100-fold selectivity over CB1.
S-777469 significantly suppressed scratching behavior induced by histamine or substance P in mice or by serotonin in rats.
S-777469 significantly suppressed DNFB-induced ear swelling in a dose-dependent manner.
S-777469 significantly alleviated mite antigen-induced atopic dermatitis-like skin lesions in NC/Nga mice.

物理化学性质&存储条件

分子量	414.477
分子式	C23H27FN2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-([6-ethyl-1-(4-fluorobenzyl)-5-methyl-2-oxo-1,2-dihydropyridine-3-carbonyl]amino)-cyclohexanecarboxylic acid

参考文献

1. Odan M, et al. Bioorg Med Chem Lett. 2012 Apr 15;22(8):2803-6.

2. Sekiguchi K, et al. Xenobiotica. 2014 Jan;44(1):48-58.

3. Haruna T, et al. Pharmacology. 2015;95(1-2):95-103.

S-777469 (S777469)

生物&药学活性

物理化学性质&存储条件

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S-777469 (S777469)

生物&药学活性

物理化学性质&存储条件

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