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首页-小分子抑制剂&激动剂-Epigenetics-Histone Demethylase-S-2101
S-2101

Chemical Structure : S-2101

CAS No.: 1239262-36-2

S-2101 (S2101)

货号: PC-61645Not For Human Use, Lab Use Only.

S-2101 is a potent lysine-specific demethylase 1 (LSD1) inhibitor with Ki of 0.61 uM.

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5 mg ¥1980 In stock
10 mg ¥3280 In stock
25 mg ¥5480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

S-2101 is a potent lysine-specific demethylase 1 (LSD1) inhibitor with Ki of 0.61 uM.
S-2101 displays weaker inhibition to MAO-B and MAO-A compared with Tranylcypromine (2-PCPA).
S-2101 protects against cisplatin-induced hair cell loss by preventing demethylation of histone H3K4 (H3K4me2).
S-2101 induces cytotoxicity in ovarian cancer lines.

物理化学性质&存储条件

分子量 311.75
分子式 C16H15F2NO.HCl
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

(1R,2S)-rel-2-[3,5-Difluoro-2-(phenylmethoxy)phenyl]cycloprpanamine hydrochloride

参考文献

1. Mimasu S, et al. Biochemistry. 2010 Aug 3;49(30):6494-503.

2. Konovalov S, et al. J Ovarian Res. 2013 Oct 29;6(1):75.

3. He Y, et al. Mol Neurobiol. 2015 Aug;52(1):196-205.

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