S-18986 |CAS:175340-20-2 Probechem Biochemicals

Chemical Structure : S-18986

CAS No.: 175340-20-2

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S-18986 (S18986)

货号: PC-61703Not For Human Use, Lab Use Only.

S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors.

规格	价格	库存
10 mg	￥1280	In stock
25 mg	￥1980	In stock
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100 mg		Get quote

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生物&药学活性

S-18986 is an orally bioavailable and BBB penetrant positive allosteric modulator of AMPA receptors.
S-18986 has nootropic and neuroprotective effects in animal studies, and induces both production of BDNF and AMPA-mediated release of noradrenaline and acetylcholine in the hippocampus and frontal cortex of the brain.

物理化学性质&存储条件

分子量	224.28
分子式	C10H12N2O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2,3,3aS,4-tetrahydro-1H-pyrrolo[2,1-c][1,2,4]benzothiadiazine, 5,5-dioxide

参考文献

1. Lockhart B, et al. Eur J Pharmacol. 2000 Aug 4;401(2):145-53.

2. Lebrun C, et al. Eur J Pharmacol. 2000 Aug 4;401(2):205-12.

3. Rosi S, et al. Neurosci Lett. 2004 May 6;361(1-3):120-3.

S-18986 (S18986)

生物&药学活性

物理化学性质&存储条件

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S-18986 (S18986)

生物&药学活性

物理化学性质&存储条件

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