S-0636 | PgQC inhibitor | Probechem Biochemicals

Chemical Structure : S-0636

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S-0636 (S0636)

货号: PC-26482Not For Human Use, Lab Use Only.

S-0636 is a potent, reversible inhibitor of zinc-dependent glutaminyl cyclase (PgQC) with Ki of 14 nM, selectively inhibits the bacterial virulence of P. gingivalis.

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生物&药学活性

S-0636 is a potent, reversible inhibitor of zinc-dependent glutaminyl cyclase (PgQC) with Ki of 14 nM, selectively inhibits the bacterial virulence of P. gingivalis.
S-0636 has successfully reduced the intracellular PgQC activity by 50% at 8 μM and had no bactericidal effects.
S-0636 significantly decreased gingipain activity, impaired hemagglutination capacity, and reduced keratinocyte invasion by 76% at 62.5 μM against P. gingivalis.
S-0636 effectively attenuates P. gingivalis pathogenicity through selective virulence factor inhibition while preserving bacterial viability and oral microbiome integrity.

物理化学性质&存储条件

分子量	325.38
分子式	C16H19N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(2-(4-(((1H-imidazo[4,5-b]pyridin-6-yl)amino)methyl)phenoxy)ethyl)guanidine

参考文献

1. Taudte N, et al. Front Oral Health. 2026 Mar 13;7:1716188.

S-0636 (S0636)

生物&药学活性

物理化学性质&存储条件

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S-0636 (S0636)

生物&药学活性

物理化学性质&存储条件

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