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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-Ryuvidine
Ryuvidine

Chemical Structure : Ryuvidine

CAS No.: 265312-55-8

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Ryuvidine (SPS8I-2)

货号: PC-62678Not For Human Use, Lab Use Only.

Ryuvidine is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ryuvidine (SPS8I-2) is a potent, selective CDK4 inhibitor with IC50 of 6.0 uM, displays >30-fold selectivity over CDK2 (IC50>100 uM).
Ryuvidine (SPS8I-2) shows potent cytototoxic activity against HL-60, A549, Col 1, HepG2 cancer cell lines with IC50 of 0.3-1.2 ug/mL.
Ryuvidine (SPS8I-2) also inhibits SETD8 with IC50 of 0.5 uM, efficiently and selectively suppresses cellular H4K20me1 at doses lower than 5 uM.

物理化学性质&存储条件

分子量 284.3
分子式 C15H12N2O2S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione

参考文献

1. Blum G, et al. ACS Chem Biol. 2014 Nov 21;9(11):2471-8.

2. Ryu CK, et al. Bioorg Med Chem Lett. 2000 Mar 6;10(5):461-4.

3. Lang E, et al. Cell Physiol Biochem. 2015;37(3):1178-86.

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