RyR2 inhibitor EL9

首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -RyR2 inhibitor EL9

Chemical Structure : RyR2 inhibitor EL9

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货号: PC-20397Not For Human Use, Lab Use Only.

RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

RyR2 inhibitor EL9 is a potent mutant RyR2 channel inhibitor, inhibits Ca2+ spark frequency (CaSF) in R176Q/+ myocytes with IC50 of 13 nM.
EL9 preferably targets the hyperactive mutant RyR2 channels.
EL9 prevented the induction of ventricular tachycardia observed in placebo-treated R176Q/+ mice, without affecting heart rate or cardiac contractility.

物理化学性质&存储条件

分子量	356.89
分子式	C18H29ClN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(diethylamino)ethyl 4-(butylamino)-5-chloro-2-methoxybenzoate

参考文献

1. Na Li, et al. Int J Cardiol. 2017 Jan 15;227:668-673.

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