RyR2 inhibitor EL20

Chemical Structure : RyR2 inhibitor EL20

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货号: PC-20396Not For Human Use, Lab Use Only.

RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM.

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生物&药学活性

RyR2 inhibitor EL20 is a potent antiarrhythmic compound, potently inhibits abnormal Ca2+ release in RyR2 R176Q myocytes with IC50 of 35.4 nM.
EL20 inhibits single-channel activity of purified RyR2 occurs in RyR2 R176Q myocytes with IC50 of 8.2 nM.
EL20 (2.5 µg/kg, i.p.) suppresses the induction of ventricular tachycardia (VT) in R176Q mice.
EL20 only inhibited RyR2 single-channels in the absence of the stabilizing protein calmodulin.

物理化学性质&存储条件

分子量	322.45
分子式	C18H30N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(diethylamino)ethyl 4-(butylamino)-2-methoxybenzoate

参考文献

1. Robert C Klipp, et al. Heart Rhythm. 2018 Apr;15(4):578-586.