Rv1625c agonist V-59 | Rv1625c agonist | Probechem Biochemicals

Chemical Structure : Rv1625c agonist V-59

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Rv1625c agonist V-59 (V-59)

货号: PC-72873Not For Human Use, Lab Use Only.

Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.

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生物&药学活性

Rv1625c agonist V-59 (V-59) is a specific small molecule agonist of the Mtb adenylyl cyclase Rv1625c, inhibits Mtb growth in macrophages (EC50=0.3 uM) in an Rv1625c-dependent mechanism.
V-59 inhibits Mtb growth in cholesterol media (EC50 0.70 uM), but not in media containing the two-carbon fatty acid acetate, or in standard rich growth media.
V-59 stimulates Rv1625c to produce cAMP, which is necessary for V-59 to inhibit Mtb growth.
Chemically activating Rv1625c via V-59 preferentially inhibits cholesterol utilization in WT Mtb, rather than equally inhibiting all lipid utilization by the bacterium.

物理化学性质&存储条件

分子量	371.376
分子式	C17H18FN7O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-(5-(4-fluorophenyl)-2H-tetrazol-2-yl)piperidin-1-yl)-2-(4-methyl-1,2,5-oxadiazol-3-yl)ethan-1-one

参考文献

1. Kaley M Wilburn, et al. PLoS Pathog. 2022 Feb 8;18(2):e1009862.

Rv1625c agonist V-59 (V-59)

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Rv1625c agonist V-59 (V-59)

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物理化学性质&存储条件

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