Ruxolitinib (INCB-018424, INCB18424)

Chemical Structure : Ruxolitinib

CAS No.: 941678-49-5

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货号: PC-45872Not For Human Use, Lab Use Only.

Ruxolitinib (INCB-018424) is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.

规格	价格	库存
50 mg	￥980	In stock
100 mg	￥1280	In stock
200 mg	￥1880	In stock
1 g		Get quote

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生物&药学活性

Ruxolitinib (INCB-018424, INCB18424) is a potent, selective, orally active JAK1/JAK2 inhibitor with IC50 of 3.3/2.8 nM, respectively.
Ruxolitinib (INCB-018424) displays modest selectivity against Tyk2 (6-fold) and marked selectivity (>130-fold) against JAK3.
Ruxolitinib (INCB-018424) inhibits IL-6 signaling (IC50=281 nM), and proliferation of JAK2V617F(+) Ba/F3 cells (IC50=127 nM).
Ruxolitinib (INCB-018424) suppresses erythroid progenitor colony formation from JAK2V617F(+) polycythemia vera patients (IC50=67 nM) in primary cultures.
Ruxolitinib (INCB-018424) markedly reduces level of inflammatory cytokines, and preferentially eliminates neoplastic cells in a mouse model of JAK2V617F(+) MPN.

物理化学性质&存储条件

分子量	306.365
分子式	C17H18N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	DMSO: ≥ 36 mg/mL; H2O: < 0.1 mg/mL
Chemical Name/SMILES	1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βR)-

参考文献

1. Quintás-Cardama A, et al. Blood. 2010 Apr 15;115(15):3109-17.

2. Fridman JS, et al. J Immunol. 2010 May 1;184(9):5298-307.

3. Verstovsek S, et al. N Engl J Med. 2010 Sep 16;363(12):1117-27.