Rupintrivir |CAS:223537-30-2 Probechem Biochemicals

Chemical Structure : Rupintrivir

CAS No.: 223537-30-2

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Rupintrivir (AG-7088;AG7088)

货号: PC-63345Not For Human Use, Lab Use Only.

Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM.

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生物&药学活性

Rupintrivir (AG-7088, AG7088) is a potent, irreversible inhibitor of human rhinovirus 3C protease, inhibits the replication of all HRV serotypes with EC50 of 23 nM and EC90 of 82 nM.
Rupintrivir (AG-7088) potently and irreversibly inhibits HRV 3C protease with an inactivation rate constant (kobs/[I]) of 1,470,000 ± 440,000 M-1 s-1 for HRV 14.
Rupintrivir (AG-7088) also potently inhibits related picornaviruses including coxsackieviruses A21 and B3, enterovirus 70, and echovirus 11.

物理化学性质&存储条件

分子量	598.672
分子式	C31H39FN4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate

参考文献

1. Patick AK, et al. Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50.

2. Dragovich PS, et al. J Med Chem. 1999 Apr 8;42(7):1213-24.

3. Matthews DA, et al. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7.

4. Zalman LS, et al. Antimicrob Agents Chemother. 2000 May;44(5):1236-41.

Rupintrivir (AG-7088;AG7088)

生物&药学活性

物理化学性质&存储条件

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Rupintrivir (AG-7088;AG7088)

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物理化学性质&存储条件

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