Runcaciguat |CAS:1402936-61-1 Probechem Biochemicals

Chemical Structure : Runcaciguat

CAS No.: 1402936-61-1

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Runcaciguat (BAY 1101042, BAY1101042)

货号: PC-36097Not For Human Use, Lab Use Only.

Runcaciguat (BAY1101042) is a potent, selective soluble guanylyl cyclase (sGC) stimulator/activator with EC50 of 6 nM in cGMP formation assay with sGC-overexpressing CHO cell.

规格	价格	库存
5 mg	￥2380	In stock
10 mg	￥3780	In stock
25 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

Runcaciguat (BAY1101042) is a potent, selective soluble guanylyl cyclase (sGC) stimulator/activator with EC50 of 6 nM in cGMP formation assay with sGC-overexpressing CHO cell.
Runcaciguat (BAY1101042) binds and activates oxidized and heme-free sGC and thereby restores NO-sGC-cGMP signaling under oxidative stress.
Runcaciguat (BAY1101042) potently and selectively activates the heme-free form of sGC, resulting in the typical profile of an sGC activator in preclinical experiments, both in vitro and in vivo.

物理化学性质&存储条件

分子量	488.328
分子式	C23H22Cl2F3NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3S)-3-{4-chloro-3-[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanamido]phenyl}-3-cyclopropylpropanoic acid

参考文献

1. PCT Int. Appl. (2018), WO 2018153899 A1 20180830.
2. PCT Int. Appl. (2012), WO 2012139888 A1 20121018.
3. Hahn MG, et al. J Med Chem. 2021 May 13;64(9):5323-5344.

Runcaciguat (BAY 1101042, BAY1101042)

生物&药学活性

物理化学性质&存储条件

参考文献

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Runcaciguat (BAY 1101042, BAY1101042)

生物&药学活性

物理化学性质&存储条件

参考文献

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