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首页-小分子抑制剂&激动剂-TGF-beta/Smad-PKC-Ruboxistaurin hydrochloride
Ruboxistaurin hydrochloride

Chemical Structure : Ruboxistaurin hydrochloride

CAS No.: 169939-93-9

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Ruboxistaurin hydrochloride (LY333531 hydrochloride, LY-333531 hydrochloride)

货号: PC-42441Not For Human Use, Lab Use Only.

Ruboxistaurin hydrochloride (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.

规格 价格 库存 数量
5 mg ￥1480 In stock
10 mg ￥2180 In stock
25 mg ￥3780 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Ruboxistaurin hydrochloride (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.
Ruboxistaurin hydrochloride (LY333531) displays >60-fold selectivity over PKCα, and other ATP dependent kinases (PKA, Calcium calmodulin, Caesin kinase and Src).
Ruboxistaurin hydrochloride (LY333531) ameliorates the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats.

物理化学性质&存储条件

分子量 505.0079
分子式 C28H29ClN4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 6.8 mg/mL (Need ultrasonic and warming)
Chemical Name/SMILES

9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, 9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-, monohydrochloride, (9S)- (9CI)

参考文献

1. Jirousek MR, et al. J Med Chem. 1996 Jul 5;39(14):2664-71.

2. Ishii H, et al. Science. 1996 May 3;272(5262):728-31.

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