Ruboxistaurin | PKCβ inhibitor | Probechem Biochemicals

Chemical Structure : Ruboxistaurin

CAS No.: 169939-94-0

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Ruboxistaurin (LY333531, LY-333531)

货号: PC-23429Not For Human Use, Lab Use Only.

Ruboxistaurin (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.

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5 mg	￥1480	In stock
10 mg	￥2180	In stock
25 mg	￥3780	In stock
50 mg	￥5980	In stock
100 mg		Get quote

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生物&药学活性

Ruboxistaurin (LY333531) is a potent, selective, ATP-competitive, orally available PKC beta (PKCβ) inhibitor with IC50 of 4.7 and 5.9 nM for PKCβ I and PKCβ II, respectively.
Ruboxistaurin hydrochloride (LY333531) displays >60-fold selectivity over PKCα, and other ATP dependent kinases (PKA, Calcium calmodulin, Caesin kinase and Src).
Ruboxistaurin hydrochloride (LY333531) ameliorates the glomerular filtration rate, albumin excretion rate, and retinal circulation in diabetic rats.

物理化学性质&存储条件

分子量	468.56
分子式	C28H28N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(7S)-7-((Dimethylamino)methyl)-22,25-dihydro-11H,21H,31H-6-oxa-1,3(3,1)-diindola-2(3,4)-pyrrolacyclononaphane-22,25-dione

参考文献

1. Jirousek MR, et al. J Med Chem. 1996 Jul 5;39(14):2664-71.

2. Ishii H, et al. Science. 1996 May 3;272(5262):728-31.

Ruboxistaurin (LY333531, LY-333531)

生物&药学活性

物理化学性质&存储条件

参考文献

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Ruboxistaurin (LY333531, LY-333531)

生物&药学活性

物理化学性质&存储条件

参考文献

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