Rubimaillin (Mollugin)

Chemical Structure : Rubimaillin

CAS No.: 55481-88-4

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货号: PC-27671Not For Human Use, Lab Use Only.

Rubimaillin (Mollugin) is a naphthohydroquinone isolated from the Chinese medical plant Rubia cordifola, strongly suppresses the secretion of hepatitis B surface antigen (HBsAg) with IC50 of 2 ug/mL in human hepatoma Hep3B cells, selectively inhibits cholesteryl ester synthesis with IC50 of 18 uM.

规格	价格	库存
10 mg	￥480	In stock
25 mg	￥780	In stock
50 mg	￥1280	In stock
100 mg		Get quote

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生物&药学活性

Rubimaillin (Mollugin) is a naphthohydroquinone isolated from the Chinese medical plant Rubia cordifola, strongly suppresses the secretion of hepatitis B surface antigen (HBsAg) with IC50 of 2 ug/mL in human hepatoma Hep3B cells, selectively inhibits cholesteryl ester synthesis with IC50 of 18 uM.
Rubimaillin (Mollugin) inhibits acyl-CoA:cholesterol acyltransferase (ACAT1) activity in ACAT1-expressing cells with IC50 of 80 uM.
Rubimaillin (Mollugin) inhibits macrophage ACAT activity in order to decrease cholesteryl ester (CE) synthesis, leading to a reduction in the number of lipid droplets.
Rubimaillin (Mollugin) inhibits the ACAT2 isozyme in ACAT2-expressing cells with IC50 of 22 uM.
Rubimaillin (Mollugin) exhibits antimutagenic activity, antitumor activity, antiviral activity, and inhibitory activity in arachidonic acid- and collagen-induced platelet aggregation.

物理化学性质&存储条件

分子量	284.31
分子式	C17H16O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate

参考文献

1. Matsuda D, et al. Biol Pharm Bull. 2009 Aug;32(8):1317-20.

2. Ho LK, et al. J Nat Prod. 1996 Mar;59(3):330-3.

3. Jeong GS, et al. Eur J Pharmacol. 2011 Mar 11;654(3):226-34.