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首页-抗体和重组蛋白-Biosimilar Antibody-Rozanolixizumab
Rozanolixizumab

Chemical Structure : Rozanolixizumab

CAS No.: 1584645-37-3

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Rozanolixizumab (Anti-human FcRn mAb, human IgG4-Lambda2; UCB7665)

货号: PC-Ab1091Not For Human Use, Lab Use Only.

Rozanolixizumab (UCB7665) is a humanised, high-affinity, human IgG4 anti-FcRn monoclonal antibody, binds to human FcRn and cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (Kd=23 pM and 25 pM, human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM, human and cynomolgus monkey, respectively. Rozanolixizumab inhibits the recycling (IC50=0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner. The neonatal Fc receptor (also FcRn, IgG recept

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Rozanolixizumab (UCB7665) is a humanised, high-affinity, human IgG4 anti-FcRn monoclonal antibody, binds to human FcRn and cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (Kd=23 pM and 25 pM, human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM, human and cynomolgus monkey, respectively. Rozanolixizumab inhibits the recycling (IC50=0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner. The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an Fc receptor which is similar in structure to the MHC class I moleculethat functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells.

物理化学性质&存储条件

分子量
分子式 Human IgG4-Lambda2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

PBS, pH 7.0 Contains no stabilizers or preservatives
Chemical Name/SMILES

Rozanolixizumab; UCB7665; UCB 7665; CA170_01519.g57 IgG4P; 1584645-37-3; Anti-human neonatal Fc receptor for IgG; Anti-human FcRn; Fcgrt gene; Anti-human Brambell receptor; IgG receptor FcRn large subunit p51

参考文献

1. 1, Kiessling P, et al. Sci Transl Med. 2017 Nov 1;9(414):eaan1208. 2, Smith B, et al. MAbs. 2018 Oct;10(7):1111-1130. 3, Zuercher AW, et al. Autoimmun Rev. 2019 Oct;18(10):102366. 4, Bril V, et al. Neurology. 2021 Feb 9;96(6):e853-e865.

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