Chemical Structure : Rozanolixizumab
CAS No.: 1584645-37-3
货号: PC-Ab1091Not For Human Use, Lab Use Only.
Rozanolixizumab (UCB7665) is a humanised, high-affinity, human IgG4 anti-FcRn monoclonal antibody, binds to human FcRn and cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (Kd=23 pM and 25 pM, human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM, human and cynomolgus monkey, respectively. Rozanolixizumab inhibits the recycling (IC50=0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner. The neonatal Fc receptor (also FcRn, IgG recept
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
1 mg | ¥3580 | In stock | |
5 mg | ¥7580 | In stock | |
10 mg | ¥12800 | In stock | |
100 mg | Get quote |
大包装,大折扣!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
Rozanolixizumab (UCB7665) is a humanised, high-affinity, human IgG4 anti-FcRn monoclonal antibody, binds to human FcRn and cynomolgus monkey FcRn with a similar affinity at both pH 6.0 (Kd=23 pM and 25 pM, human and cynomolgus monkey, respectively) and pH 7.4 (34 pM and 53 pM, human and cynomolgus monkey, respectively. Rozanolixizumab inhibits the recycling (IC50=0.41 nM) of human IgG by human FcRn-transfected MDCK cells in a dose-dependent manner. The neonatal Fc receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene. It is an Fc receptor which is similar in structure to the MHC class I moleculethat functions to protect IgG and albumin from catabolism, mediates transport of IgG across epithelial cells, and is involved in antigen presentation by professional antigen presenting cells.
分子量 | ||
分子式 | Human IgG4-Lambda2 | |
外观性状 | Solid | |
储存条件 |
|
|
Solubility |
PBS, pH 7.0 Contains no stabilizers or preservatives |
|
Chemical Name/SMILES |
Rozanolixizumab; UCB7665; UCB 7665; CA170_01519.g57 IgG4P; 1584645-37-3; Anti-human neonatal Fc receptor for IgG; Anti-human FcRn; Fcgrt gene; Anti-human Brambell receptor; IgG receptor FcRn large subunit p51 |
1. 1, Kiessling P, et al. Sci Transl Med. 2017 Nov 1;9(414):eaan1208. 2, Smith B, et al. MAbs. 2018 Oct;10(7):1111-1130. 3, Zuercher AW, et al. Autoimmun Rev. 2019 Oct;18(10):102366. 4, Bril V, et al. Neurology. 2021 Feb 9;96(6):e853-e865.
备案号:沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright