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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Indoleamine 2,3-Dioxygenase (IDO)-Roxyl-WL
Roxyl-WL

Chemical Structure : Roxyl-WL

CAS No.: 667887-37-8

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Roxyl-WL

货号: PC-35526Not For Human Use, Lab Use Only.

Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    Roxyl-WL is a highly potent and selective inhibitor of IDO1 with IC50 of 1 nM.
    Roxyl-WL displays excellent kinase spectrum selectivity with no activity out of the 337 protein kinases.
    Roxyl-WL effectively augmentes the proliferation of T cells and reduces the number of regulatory T cell (Tregs).
    Roxyl-WL significantly suppresses tumor growth and induces immune response in melanoma (B16F10) tumor-bearing mice orally.

    物理化学性质&存储条件

    分子量 370.372
    分子式 C20H14N6O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1,5-dibenzylbenzo[1,2-d:4,5-d']bis([1,2,3]triazole)-4,8(1H,5H)-dione

    参考文献

    1. Xu G, et al. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1089-1094.

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