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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-HIF/HIF Prolyl-hydroxylase-Roxadustat
Roxadustat

Chemical Structure : Roxadustat

CAS No.: 808118-40-3

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Roxadustat (FG4592, FG-4592)

货号: PC-43531Not For Human Use, Lab Use Only.

Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM.

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100 mg ￥1580 In stock
500 mg ￥2680 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Roxadustat (FG4592, FG-4592) is a potent, orally available HIF prolyl hydroxylase (HIF-PHD) with IC50 of 591.4 nM.
FG-4592 stimulates erythropoiesis, regulates iron metabolism, and reduces hepcidin, demonstrates potential for treatment of anemia.

物理化学性质&存储条件

分子量 352.3407
分子式 C19H16N2O5
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: ≥ 46 mg/mL
Chemical Name/SMILES

Glycine, N-[(4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinyl)carbonyl]-

参考文献

1. Besarab A, et al. J Am Soc Nephrol. 2016 Apr;27(4):1225-33.

2. Wu Y, et al. J Med Chem. 2018 Jun 28;61(12):5332-5349.

3. Provenzano R, et al. Clin J Am Soc Nephrol. 2016 Jun 6;11(6):982-91.

4. Jain IH, et al. Science. 2016 Apr 1;352(6281):54-61.

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