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首页-小分子抑制剂&激动剂-GPCR-Dopamine Receptor-Rotigotine
Rotigotine

Chemical Structure : Rotigotine

CAS No.: 99755-59-6

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Rotigotine

货号: PC-45959Not For Human Use, Lab Use Only.

A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM).

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50 mg ￥2240 In stock
100 mg ￥3200 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

A non-selective agonist of the dopamine D3 receptor (Ki=0.71 nM); has 10-fold selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor; behaves as a full agonist of D1, D2, and D3 with similar potencies (EC50) in functional assay; also demonstrates significant affinity at α-adrenergic (α2B, Ki=27 nM) and serotonin receptors (5-HT1A Ki=30 nM); significantly attenuates MPTP-induced acute cell degeneration in mouse model.

Parkinson's Disease

Approved

物理化学性质&存储条件

分子量 315.4729
分子式 C19H25NOS
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-Naphthalenol, 5,6,7,8-tetrahydro-6-[propyl[2-(2-thienyl)ethyl]amino]-, (6S)-

参考文献

1. Wood M, et al. Br J Pharmacol. 2015 Feb;172(4):1124-35.

2. Scheller D, et al. Naunyn Schmiedebergs Arch Pharmacol. 2009 Jan;379(1):73-86.

3. Scheller D, et al. Neurosci Lett. 2008 Feb 13;432(1):30-4.

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