Rostafuroxin |CAS:156722-18-8 Probechem Biochemicals

Chemical Structure : Rostafuroxin

CAS No.: 156722-18-8

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Rostafuroxin (PST-2238;PST2238;PST 2238)

货号: PC-42946Not For Human Use, Lab Use Only.

Rostafuroxin (PST2238) is potent, selective, orally active Na-K-ATPase inhibitor, displaces 3H ouabain from dog kidney Na+,K+-ATPase with IC50 of 1.5 nM.

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10 mg	￥1280	In stock
50 mg	￥4280	In stock
100 mg	￥7280	In stock
500 mg		Get quote

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生物&药学活性

Rostafuroxin (PST2238) is potent, selective, orally active Na-K-ATPase inhibitor, displaces 3H ouabain from dog kidney Na+,K+-ATPase with IC50 of 1.5 nM; displays excellent selectivity over a panel of general and hormonal receptors, with exception of thromboxane A2 receptor (61% inhibition at 1 uM); abolishes ouabain-dependent increase in the Na-K pump rate in cultured renal cells, abolishes the increase in blood pressure and renal Na-K ATPase activity caused by ouabain in rats model of hypertension.

Hypertension

Phase 2 Clinical

物理化学性质&存储条件

分子量	374.5137
分子式	C23H34O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	24-Norchola-20,22-diene-3,14,17-triol, 21,23-epoxy-, (3β,5β,14β)-

参考文献

1. Quadri L, et al. J Med Chem. 1997 May 23;40(11):1561-4.

2. Ferrari P, et al. J Pharmacol Exp Ther. 1998 Apr;285(1):83-94.

3. Goto A, et al. Hypertension. 1997 Sep;30(3 Pt 2):753-8.

4. Ferrari P, et al. J Pharmacol Exp Ther. 1999 Mar;288(3):1074-83.

Rostafuroxin (PST-2238;PST2238;PST 2238)

生物&药学活性

物理化学性质&存储条件

参考文献

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Rostafuroxin (PST-2238;PST2238;PST 2238)

生物&药学活性

物理化学性质&存储条件

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