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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-Rosolutamide
Rosolutamide

Chemical Structure : Rosolutamide

CAS No.: 1039760-91-2

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Rosolutamide (ASC-JM17)

货号: PC-25023Not For Human Use, Lab Use Only.

Rosolutamide (ASC-JM17) is a curcumin analog, an orally active, potent Nrf1 and Nrf2 activator, activates Nrf1, Nrf2, and heat shock factor 1 (Hsf1), which in turn activates the expression of proteasome subunits, antioxidant enzymes, and molecular chaperones.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

Rosolutamide (ASC-JM17) is a curcumin analog, an orally active, potent Nrf1 and Nrf2 activator, activates Nrf1, Nrf2, and heat shock factor 1 (Hsf1), which in turn activates the expression of proteasome subunits, antioxidant enzymes, and molecular chaperones.

物理化学性质&存储条件

分子量 464.56
分子式 C28H32O6
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(1E,6E)-4-(cyclobutylmethyl)-1,7-bis(3,4-dimethoxyphenyl)hepta-1,6-diene-3,5-dione

参考文献

1. Laura C Bott, et al. Hum Mol Genet. 2016 May 15;25(10):1979-1989.

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