Rosiglitazone | PPARγ agonist | Probechem Biochemicals

Chemical Structure : Rosiglitazone

CAS No.: 122320-73-4

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Rosiglitazone (BRL-49653, BRL49653)

货号: PC-45209Not For Human Use, Lab Use Only.

Rosiglitazone (BRL49653) is a potent and selective PPARγ agonist that binds to the PPARγ ligand-binding domain with a Kd of 40 nM.

规格	价格	库存
10 mg (Free Sample)	￥280	In stock
50 mg	￥880	In stock
100 mg	￥1280	In stock
250 mg	￥1880	In stock
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生物&药学活性

Rosiglitazone (BRL49653) is a potent and selective PPARγ agonist that binds to the PPARγ ligand-binding domain with a Kd of 40 nM.
Rosiglitazone (BRL49653) is an antidiabetic agent that has been used as an oral hypoglycemic agent in the treatment of Type II diabetes.
Rosiglitazone (BRL49653) also inhibits TRP channels TRPM2 and TRPM3 with IC50 of 22.5 uM and 5-10 uM, respectively.
Rosiglitazone (BRL49653) also increases klotho and decreases Wnt5A in tumor cells.

物理化学性质&存储条件

分子量	357.4268
分子式	C18H19N3O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 180 mg/mL
Chemical Name/SMILES	2,4-Thiazolidinedione, 5-[[4-[2-(methyl-2-pyridinylamino)ethoxy]phenyl]methyl]-

参考文献

1. Lehmann JM, et al. J Biol Chem. 1995 Jun 2;270(22):12953-6.

2. Majeed Y, et al. Mol Pharmacol. 2011 Jun;79(6):1023-30.

3. Behera R, et al. Clin Cancer Res. 2017 Jun 15;23(12):3181-3190.

Rosiglitazone (BRL-49653, BRL49653)

生物&药学活性

物理化学性质&存储条件

参考文献

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Rosiglitazone (BRL-49653, BRL49653)

生物&药学活性

物理化学性质&存储条件

参考文献

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