Romidepsin | HDAC inhibitor | Probechem Biochemicals

Chemical Structure : Romidepsin

CAS No.: 128517-07-7

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Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide)

货号: PC-20784Not For Human Use, Lab Use Only.

Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide) is a natrual produrct from Chromobacterium violaceum as class I HDACs inhibitor, inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1400 nM, respectively.

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10 mg	￥3980	In stock
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生物&药学活性

Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide) is a natrual produrct from Chromobacterium violaceum as class I HDACs inhibitor, inhibits HDAC1, HDAC2, HDAC4, and HDAC6 with IC50s of 36 nM, 47 nM, 510 nM and 1400 nM, respectively.
Romidepsin (FK228) has demonstrated potent in vitro and in vivo cytotoxic activity against murine and human tumor cell lines.
Romidepsin (FK228) strongly inhibited the growth of U-937 cells with IC50 of 5.92 nM.
Romidepsin (FK228) prolonged the survival time of scid mice in a lymphoma model.
Romidepsin (FK228) showed beneficial effects of FK228 on human lymphoma may be exerted through the induction of apoptosis, cell cycle arrest, and differentiation via the modulation of gene expression by histone acetylation.

物理化学性质&存储条件

分子量	540.69
分子式	C24H36N4O6S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-diisopropyl-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo[8.7.6]tricos-16-ene-3,6,9,19,22-pentaone

参考文献

1. Ueda H, et al. J Antibiot (Tokyo). 1994 Mar;47(3):301-10.

2. Furumai R, et al. Cancer Res. 2002 Sep 1;62(17):4916-21.

3. Piekarz RL, et al. Blood. 2001 Nov 1;98(9):2865-8.

4. Sasakawa Y, et al. Biochem Pharmacol. 2002 Oct 1;64(7):1079-90.

Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide)

生物&药学活性

物理化学性质&存储条件

参考文献

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Romidepsin (FK228, NSC 63017, R 901228, Depsipeptide)

生物&药学活性

物理化学性质&存储条件

参考文献

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