Rolofylline (KW-3902) | A1AR antagonist | Probechem Biochemicals

Chemical Structure : Rolofylline

CAS No.: 136199-02-5

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Rolofylline (KW3902, KW-3902)

货号: PC-61328Not For Human Use, Lab Use Only.

Rolofylline (KW-3902) is a potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
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生物&药学活性

Rolofylline (KW-3902) is a potent, selective and orally active adenosine A1 receptor antagonist with Ki of 1.3 nM.
Rolofylline (KW3902) displays 290-fold selectivity over A2AR.
Rolofylline (KW3902) antagonizes NECA-induced bradycardic response in anesthetized rats (0.1-1mg/kg), causes significant increases of urine volume and sodium excretion with little change of potassium excretion in saline-loaded normal rats (0.001-1 mg/kg).

物理化学性质&存储条件

分子量	356.46
分子式	C20H28N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	8-(hexahydro-2,5-methanopentalen-3a(1H)-yl)-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione

参考文献

1. Mizumoto H, et al. J Pharmacol Exp Ther. 1993 Jul;266(1):200-6.

2. Shimada J, et al. J Med Chem. 1992 Mar 6;35(5):924-30.

Rolofylline (KW3902, KW-3902)

生物&药学活性

物理化学性质&存储条件

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Rolofylline (KW3902, KW-3902)

生物&药学活性

物理化学性质&存储条件

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