Rolipram (SB95952, ZK62711) | PDE4 inhibitor | Probechem Biochemicals

Chemical Structure : Rolipram

CAS No.: 61413-54-5

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Rolipram (SB95952, ZK62711, (R,S)-Rolipram, (±)-Rolipram)

货号: PC-45080Not For Human Use, Lab Use Only.

Rolipram (SB95952, ZK62711) is a potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

规格	价格	库存
50 mg	￥580	In stock
100 mg	￥880	In stock
250 mg	￥1380	In stock
1 g		Get quote

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生物&药学活性

Rolipram (SB95952, ZK62711) is a potent, selective inhibitor of phosphodiesterases PDE4 with IC50 of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Rolipram increases phosphorylation of CREB in U937 cells in a dose-dependent fashion, dose-dependently inhibits the IFN-gamma-stimulated phosphorylation of p38 MAPK with IC50 of 290 nM.
Rolipram inhibits TNF production, attenuates carrageenan-induced paw inflammation in mice.

物理化学性质&存储条件

分子量	275.3428
分子式	C16H21NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 41 mg/mL
Chemical Name/SMILES	2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-

参考文献

1. MacKenzie SJ, et al. Biochem J. 2000 Apr 15;347(Pt 2):571-8.

2. Korhonen R, et al. Br J Pharmacol. 2013 Aug;169(7):1525-36.

3. Shalaby AM, et al. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.

Rolipram (SB95952, ZK62711, (R,S)-Rolipram, (±)-Rolipram)

生物&药学活性

物理化学性质&存储条件

参考文献

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询单

Rolipram (SB95952, ZK62711, (R,S)-Rolipram, (±)-Rolipram)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

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