Rofecoxib | COX-2 inhibitor | Probechem Biochemicals

Chemical Structure : Rofecoxib

CAS No.: 162011-90-7

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Rofecoxib (MK-0996, MK-966)

货号: PC-45194Not For Human Use, Lab Use Only.

Rofecoxib (MK-0996) is a potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells.

规格	价格	库存
100 mg	￥480	In stock
250 mg	￥780	In stock
1 g	￥1480	In stock
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生物&药学活性

Rofecoxib (MK-0996) is a potent, selective and orally active COX-2 inhibitor with IC50 of 26 nM for inhibition of the COX-2-dependent production of PGE2 in human osteosarcoma cells.
Rofecoxib (MK-0996) displays 1,000-fold selectivity over COX-1 activity.
Rofecoxib (MK-0996) selectively inhibits LPS-induced, COX-2-derived PGE(2) synthesis after blood coagulation (IC50=0.53 uM).
Rofecoxib (MK-0996) exhibits anti-inflammation activity in osteoarthritis and rheumatoid arthritis rodent models.

物理化学性质&存储条件

分子量	314.3557
分子式	C17H14O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2(5H)-Furanone, 4-[4-(methylsulfonyl)phenyl]-3-phenyl-

参考文献

1. Chan CC, et al. J Pharmacol Exp Ther. 1999 Aug;290(2):551-60.

2. Ehrich EW, et al. Clin Pharmacol Ther. 1999 Mar;65(3):336-47.

3. Prasit P, et al. Bioorg Med Chem Lett. 1999 Jul 5;9(13):1773-8.

Rofecoxib (MK-0996, MK-966)

生物&药学活性

物理化学性质&存储条件

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Rofecoxib (MK-0996, MK-966)

生物&药学活性

物理化学性质&存储条件

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