Ro 90-7501

Chemical Structure : Ro 90-7501

CAS No.: 293762-45-5

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货号: PC-73339Not For Human Use, Lab Use Only.

Ro 90-7501 is a prototypic inhibitor for Abeta42 (Aβ42) fibril formation, reduces Aβ42-induced cytotoxicity (EC50=2 uM), also enhances TLR3 and RLR agonist induced antiviral response.

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10 mg	￥1280	In stock
25 mg	￥2180	In stock
50 mg	￥3680	In stock
100 mg		Get quote

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生物&药学活性

Ro 90-7501 is a prototypic inhibitor for Abeta42 (Aβ42) fibril formation, reduces Aβ42-induced cytotoxicity (EC50=2 uM), also enhances TLR3 and RLR agonist induced antiviral response.
Ro 90-7501 also inhibits protein phosphatase 5 (PP5) through a TPR-dependent mechanism.
Ro 90-7501 also showed significant radiosensitizing effects in clonogenic survival and tumor growth delay assays suppressed the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2, after irradiation.

物理化学性质&存储条件

分子量	340.390
分子式	C20H16N6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2'-(4-Aminophenyl)-1H,3'H-[2,5'-bibenzo[d]imidazol]-5-amine

参考文献

1. Bohrmann B, et al. J Struct Biol. 2000 Jun;130(2-3):232-46.

2. Guo F, et al. PLoS One. 2012;7(10):e42583.

3. Hong TJ, et al. Biochem Biophys Res Commun. 2017 Jan 8;482(2):215-220.

4. Tamari K, et al. Anticancer Res. 2019 Sep;39(9):4805-4810.

Ro 90-7501

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物理化学性质&存储条件

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Ro 90-7501

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物理化学性质&存储条件

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