Ro 64-6198 hydrochloride |CAS:309254-79-3 Probechem Biochemicals

Chemical Structure : Ro 64-6198 hydrochloride

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Ro 64-6198 hydrochloride (Ro 646198 hydrochloride)

货号: PC-61543Not For Human Use, Lab Use Only.

Ro 64-6198 hydrochloride is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41.

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生物&药学活性

Ro 64-6198 hydrochloride is a nonpeptidic, selective, brain-penetrant agonist of nociceptin/orphanin FQ receptor (NOP receptor/ORL1) with pKi of 9.41.
Ro 64-6198 displays >100-fold selectivity for ORL1 over other members of opioid receptor family.
Ro 64-6198 elicits dose-dependent anxiolytic-like effects in models of distinct types of anxiety states in rata, with no efficient anti-panic-like activity, absence of anticonvulsant properties, and lack of effects on motor performance and cognitive function at anxiolytic doses (0.3 to 3 mg/kg i.p.).

物理化学性质&存储条件

分子量	438.012
分子式	C26H32ClN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-((1S,3aS)-2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one hydrochloride

参考文献

1. Chang SD, et al. ACS Chem Neurosci. 2015 Dec 16;6(12):1956-64.

2. Saccone PA, et al. J Pharmacol Exp Ther. 2016 Apr;357(1):17-23.

3. Jenck F, et al. Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4938-43.

Ro 64-6198 hydrochloride (Ro 646198 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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Ro 64-6198 hydrochloride (Ro 646198 hydrochloride)

生物&药学活性

物理化学性质&存储条件

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